|
T14349 |
Auristatin F
|
|
Microtubule Associated
|
|
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates. |
|
T14348 |
Auristatin E
|
|
Microtubule Associated
|
|
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an... |
|
T38889 |
Thailanstatin A
|
|
|
|
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s... |
|
T11249L |
Dxd
|
Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ |
Topoisomerase
|
|
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. |
|
T15141 |
DM4
|
Ravtansine |
Others
,
Microtubule Associated
|
|
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division. |
|
T11120 |
Duocarmycin TM
|
|
DNA Alkylation
,
Antibiotic
|
|
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic. |
|
T3256 |
MMAF
|
MonoMethyl auristatin F |
Others
,
Microtubule Associated
|
|
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin. |
|
T8003 |
Methotrexate disodium
|
|
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
|
T12081 |
MMAF-OMe
|
Monomethyl auristatin F methyl ester |
|
|
MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji ... |
|
T1992 |
Mertansine
|
DM1,Maytansinoid DM1 |
Microtubule Associated
|
|
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4... |
|
T6897 |
Monomethyl auristatin E
|
Vedotin,MMAE |
Apoptosis
,
Microtubule Associated
|
|
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity. |
|
T16557 |
PNU-159682
|
|
Topoisomerase
|
|
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin. |
|
T21408 |
DM1-SMe
|
DM1-SSMe |
Microtubule Associated
|
|
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ... |
|
T14858 |
Calicheamicin
|
Calicheamicin γ1 |
Others
|
|
|
|
T1910 |
Ansamitocin P 3'
|
Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3' |
Microtubule Associated
|
|
Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity. |
|
T4677 |
MMAD
|
Monomethylauristatin D,Demethyldolastatin 10,Monomethyl Dolastatin 10 |
Microtubule Associated
|
|
MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs). |
|
T1485 |
Methotrexate
|
NCI-C04671,WR19039,Amethopterin,CL14377 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
|
|
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... |
|
T41248 |
Thiocolchicine
|
|
Microtubule Associated
|
|
Thiocolchicine is an effective inhibitor of tubulin polymerization with an IC50 of 2.5 µM and a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis. Thiocolchicine can be used as an ADC cytotoxin in ADC technology. |
|
T17802 |
DBCO-PEG4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of ... |
|
T13658 |
DMEA-PNU-159682
|
|
Others
|
|
DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule, including neomycin (MMDX) metabolites from liver microsomes and effective ADC cytotoxin PNU-159682. |
|
T19300 |
Duocarmycin Analog
|
|
DNA Alkylation
|
|
Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin. |
|
T10640 |
C-11
|
|
Others
|
|
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines. |
|
T38430 |
Tubulysin IM-2
|
|
|
|
Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins . |
|
T18302 |
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 ... |
|
T19254 |
Cyclooctyne-O-NHS ester
|
|
Others
|
|
Cycloctyne-O-NHS ester is a derivative of cyclooctyne, which will seriously damage HEK293 cells and be used as ADC cytotoxin. |
|
T39582 |
2',3'-cGAMP-C2-SH
|
2',3'-cGAMP-C2-SH |
|
|
2', 3'-cGAMP-C2-SH is a ADC cytotoxin. |
|
T18292 |
Mal-PEG4-VC-PAB-DMEA-PNU-159682
|
|
Others
|
|
Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, D... |
|
T18246 |
Mal-C2-Gly3-EDA-PNU-159682
|
|
Others
|
|
Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682. |
|
T12813L |
Seco-Duocarmycin SA
|
|
DNA Alkylation
|
|
Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin. |
|
T40191 |
17-GMB-APA-GA
|
|
|
|
17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection. |
|
T73947 |
Tubulysin IM-1
|
|
|
|
Tubulysin IM-1, functioning as an ADC (Antibody-Drug Conjugate) cytotoxin and a tubulin binder, serves as an anti-microtubule toxin [1]. |
|
T60321 |
Tubulysin IM-3
|
|
|
|
Tubulysin IM-3 is an ADC Cytotoxin as well as tubulin binder. Tubulysin IM-3 can be used as anti-microtubule toxins. |
|
T18304 |
Mal-VC-PAB-ABAEP-Azonafide
|
|
Others
|
|
Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1]. |
|
T12813 |
(S)-Seco-Duocarmycin SA
|
|
Others
|
|
(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates. |
|
T63713 |
Mytoxin B
|
|
|
|
Mytoxin B is a macrocyclic endolipid that acts like LY294002 and is also an ADC cytotoxin (ADC cytotoxin). mytoxin B is able to exploit the PI3K/Akt pathway and thus induce apoptosis. |
|
T10972 |
DC4
|
|
Others
|
|
DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors. |
|
T39138 |
Muscotoxin A
|
|
|
|
Muscotoxin A is an ADC cytotoxin with lipopeptide properties that effectively permeabilizes mammalian cell membranes, ultimately inducing necrotic cell death. |
|
T77901 |
Ac-Exatecan
|
|
Topoisomerase
|
|
Ac-Exatecan, the acetylated form of Exatecan (DX-8951), serves as a prevalent cytotoxic agent in antibody-drug conjugate (ADC) formulations (ADC Cytotoxin) and acts as an inhibitor of DNA topoisomerase I with an IC50 val... |
|
T77889 |
NH2-methylpropanamide-Exatecan TFA
|
|
Topoisomerase
|
|
Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.975 μg/mL), utilized in the synthesis of ADCs for cancer res... |
|
T74367 |
SC209
|
|
|
|
SC209, an ADC cytotoxin is used in synthesis of anti- EGFR antibody-drug conjugate ADC. SC209 is a metabolite of STRO-002 [1] [2] . |
|
T17740 |
Cyclooctyne-O-PFP ester
|
|
Others
|
|
Cyclooctyne-O-PFP ester is a used as an ADC cytotoxin, which connects antibody and linker[1]. |
|
T77872 |
S-Me-DM4
|
|
|
|
S-Me-DM4 is an intracellular enzyme S-methylated metabolite of DM4, a maytansinoid with microtubule-depolymerizing properties and potent cytotoxicity, employed as an Antibody-Drug Conjugate (ADC) cytotoxin [1]. |
|
T74177 |
Modified MMAF
|
|
|
|
Modified MMAF, a cytotoxin for antibody-drug conjugates (ADC), facilitates the synthesis of ADCs tailored for targeted cancer research [1]. |
|
T82382 |
Fmoc-MMAF-OMe
|
|
|
|
Fmoc-MMAF-OMe is a tubulin polymerization inhibitor and anticancer agent featuring an Fmoc protecting group. Its active component, MMAF, serves as the cytotoxic (ADC Cytotoxin) element in conventional antibody-drug conju... |
|
T10970 |
DC1
|
|
Others
|
|
DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer, is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. |
|
T15158 |
Dolastatin 15
|
DLS 15 |
Others
|
|
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces c... |
|
T11046 |
Dimethyl-SGD-1882
|
Dimethyl-PBD dimer |
Others
|
|
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication. |
|
T10969 |
DC1SMe
|
|
Others
|
|
DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 ... |
|
T61390 |
D18
|
|
|
|
D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increa... |
|
T11682 |
Isofistularin-3
|
|
Others
|
|
Isofistularin-3, a direct DNA-competitive DNMT1 inhibitor with an IC50 of 13.5 μM, functions as a DNA demethylating agent, leading to cell cycle arrest and increased sensitivity to TRAIL in cancer cells. Additionally, it... |
